NAD+ IV Therapy in Edmonton
Dr. Muradov offers Edmonton IV NAD Therapy.
We have numerous IV Therapy treatments available at our office.
Nicotinamide adenine dinucleotide (NAD+) is present in all cells of the body and is crucial for cell viability and function.
NAD+ is a cofactor essential for operation of the Krebs Cycle and Electron Transport Chain for body wide ATP production.
The phosphorylated metabolite of NAD+, NADP+ with its redox couple NADPH drives a number of reactions, including cholesterol and nucleic acid synthesis, and regeneration of glutathione.
NAD+ activates Sirtuin pathways of which, Sirtuin1 (SIRT1) is the pathway associated with longevity as well as the PARP enzyme family that controls DNA repair.
The clinical importance of maintaining cellular NAD+ levels was established initially with the finding that pellagra, which is characterized by diarrhea, dermatitis, dementia and death, could be cured with foods containing the NAD+ precursor niacin (Vitamin B3). Our Naturopaths tend to give Niacinamide during IV therapy - Niacinamide and Niacin are chemically interconvertable.
Cellular concentrations of NAD+ have been shown to decrease under conditions of increased oxidative damage such as aging which is partly why NAD+ is given as a longevity promoting substance. Interventions targeted at restoring NAD+ levels have been shown in animal models to support healthy aging and improve metabolic function and cognitive function.
Our clinic usually doses NAD+ Intravenously anywhere from 250-2000mg. However, doses between 250-500mg are most often given for fatigue whereas doses beyond 1000mg are typically for substance withdrawal.
See an article discussing pharmacokinetics of IV NAD+
Our Naturopaths tend to suggest NAD+ IV Therapy in a few common scenarios: Fatigue, Longevity, Substance Withdrawal and issues where mitochondrial function is thought to be affected like Fibromyalgia.
NAD+ as a treatment is relatively new however robust data exists for NADH (reduced version)
One such study "Therapeutic effects of oral NADH on the symptoms of patients with chronic fatigue syndrome" where oral NADH (10mg) in Chronic Fatigue Syndrome improved Fatigue, Cognition, muscle aches and weakness and sleep.
In our experience, the use of IV NAD Therapy provides much more robust results that oral NADH, but our Naturopaths may recommend NADH as a bridging treatment between NAD+ IV Treatments.
We also have experience giving IV NADH for neurodegenerative disease and instances where we suspect mitochondrial defects. In general, we've seen more profound responses with IV NAD+ than IV NADH. IV NADH is given more rapidly than IV NAD+ and does not have anywhere near the same side effects as NAD+.
Fairly robust data exists for the use of IV Therapy with NADH in Parkinson's in particular - see Birkmayer 1993.
Other studies exist evaluating NADH and CoQ10 for Chronic Fatigue Syndrome with positive results as well. So CoQ10 is often an oral consideration our Naturopaths suggest in conjunction with IV NAD+ Therapy.
However our Naturopaths have a preference for using NR in conjunction with IV NAD+ as NR has been shown to effectively increase NAD+ levels in the blood.
IV NAD Administration
IV NAD Therapy is usually given over 1-2 hours for fatigue, and 3-12 hours for substance abuse.
Our Naturopaths often suggest front loading the IV NAD with a few consecutive days of administration at the outset. However, once weekly treatments are efficacious as well, with patients needing a booster ever 2-4 weeks in many cases which is why we insist on some sort of oral NAD+ repletion.
NAD+ can give profound nausea when the IV treatment is given too rapidly.
Infused NAD+ is rapidly and completely removed from the plasma (taken up by cells) for the first two hours of IV administration.
Enzymes indicative of hepatic stress such as the intrahepatic LD and AST and the post-hepatic (bile duct) enzyme GGT all decline immediately following NAD+ IV Therapy suggesting that the integrity of these tissues is in fact enhanced following NAD IV Therapy.
IV NAD treatments can be enhanced with the inclusion of a Myers' Cocktail IV treatment. The B-Vitamins and Magnesium in particular can help drive the Krebs cycle and enhance effects seen especially with regards to fatigue. The B-Vitamins and NAD+ can be co-administered in one IV Therapy treatment for simultaneous synergistic effect.
IV Glutathione can easily be added to the tail end of NAD+ IV Therapy for enhanced longevity enhancing effects as Glutathione is thought to protect mitochondrial DNA.
NAD+ and Withdrawal
IV NAD was originally used for alcoholism and it appears to be less effective for tobacco and marijuana. For marijuana and tobacco, NAC (N-acetyl cysteine) is one of our top Naturopathic recommendations typically. Our Naturopathic Doctors often use Vitamin C, B1 and B3 in addition to IV NAD+ for alcohol cessation.
For substance abuse, NAD IV Therapy can be anywhere from 3 - 10 consecutive days.
Alcohol, Cocaine and Crystal meth are thought to be the best candidates for NAD IV Therapy.
Benzodiazepines (lorazepam, clonazepam, diazepam) are thought to be the hardest (may require up to 15 days).
NAD IV Therapy in Edmonton
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