Glutathione IV Therapy in Edmonton
Our Naturopaths are experienced with IV Glutathione Treatment.
Glutathione is a potent antioxidant that interacts with reactive oxygen species & reactive nitrogen species.
Glutathione’s mechanism of action involves enzyme glutathione peroxidase (GPx) which converts Glutathione to its oxidized form "GSSG" and glutathione reductase (GR) - which reduces "GSSG" back to Glutathione "GSH".
Glutathione has a profound role in the brain as a detoxifying agent because of the brain's vulnerability towards oxidative stress (as it utilizes 20% of the O2 consumed by the body whereas constitutes only 2% of body weight).
Depleted levels of Glutathione is implicated in the cell death in various neurological diseases like Alzheimer’s disease, Parkinson’s disease, and Multiple Sclerosis and for this reason our Naturopathic doctors use IV Glutathione therapy in these diseases.
An interesting case report was published in 2018 detailing a Parkinson's patient with reasonable benefit from moderate dose Glutathione IV Therapy.
The large spike in blood Glutathione that occurs with IV Therapy is thought to move more Glutathione into the brain as opposed to what can be achieved orally with low dose, "absorbable" liposomal Glutathione preparations.
Glutathione does have some cosmetic benefits in some patients when given Intravenously primarily. So occasionally our Naturopathic doctors use Glutathione IV Therapy for cosmetic "brightening" and "lightening" purposes.
In a 2012 study, medical students were given either glutathione capsules, or placebo for 4 weeks and a lightening of the skin was seen (the melanin indices decreased consistently) in those who received glutathione.
We usually recommend patients complement their cosmetic IV Therapy along with oral Glutathione.
See a comprehensive Glutathione review by Pizzorno.
IV Glutathione In-Depth:
Glutathione is found in the cytosol of all mammalian tissues
Glutathione is synthesized using constituent amino acids Glutamine, Cysteine and Glycine therefore our Naturopathic doctors often recommend acetylated Cysteine or "NAC" to increase Glutathione orally.
Glutathione is synthesized in all cell types with the maximum Glutathione synthesized and exported from the liver.
Glutathione is also responsible for detoxification of xenobiotics, either directly by conjugating or acting as a substrate in conjugation reactions for this reason our Naturopaths often use IV Glutathione or its precursors to "improve" liver function or aid in hormone removal.
GSH is known to cross the Blood Brain Barrier through Na-dependent Glutathione transporter.
So IV Therapy administration can certainly increase nervous system levels of Glutathione hence the use of Glutathione IV Therapy in neurological disorders.
In the brain, Glutathione neutralizes of redox-active metals like copper and iron as metal induced toxicity and interactions with cellular components have been associated with neurodegenerative disorders.
Glutathione is involved in the maintenance of optimal cytokine levels.
Pro-inflammatory cytokines like tumor necrosis factor-α (TNF-α), Interleukin-1β (IL-1β) and IL-6 reduce with Glutathione administration therefore our Naturopaths also like IV Glutathione Therapy in Autoimmune diseases hence its use in MS.
Glutathione is easily added to the end of other IV Therapy treatments.
Curious about IV Glutathione?
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